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Clinical Experience With Topiramate Dosing and Serum Levels in Children 12 Years or Under With EpilepsyTexas Comprehensive Epilepsy Program, Department of Neurology, University of Texas-Houston, Houston, TX
Texas Comprehensive Epilepsy Program, Department of Neurology, University of Texas-Houston, Houston, TX, james.w.wheless{at}uth.tmc.edu
Only a limited topiramate dosing range (5—9 mg/kg/day) is approved by the U.S. Food and Drug Administration (FDA). We reviewed our topiramate dosing (mg/kg/d) and corresponding serum levels (µg/mL) (n = 77) in 41 children who were treated to clinical response or tolerability. The patients were divided into older (6—12 years [n = 21]) and younger (
Journal of Child Neurology, Vol. 16, No. 11,
806-808 (2001) |
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5 years [n = 20]) groups. Topiramate was given as monotherapy (n = 9), with an enzyme-inducing antiepileptic drug (n = 16) (phenobarbital, phenytoin, or carbamazepine), or as polytherapy (n =17) (another antiepileptic drug). In the older children, there was a good dosage to serum level correspondence. However, younger children on topiramate monotherapy or co-therapy with an enzyme-inducing antiepileptic drug had relatively lower serum levels, but the serum level was increased if they were on polytherapy without an enzyme-inducing drug. This study supports a wider dosing range (7—22 mg/kg/day) of topiramate and dosage escalation beyond the approved range. Serum levels are useful in guiding topiramate dosing, especially in young children. (J Child Neurol 2001;16:806—808).