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Journal of Child Neurology
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Activated Protein C Resistance and False Type 2 Protein C Deficiency Detected After Multiple Shunt Failures in a Patient With Hydrocephalus

Sinan Mahir Kayiran, MD

Department of Pediatrics

Namik Özbek, MD

Department of Pediatrics, Baskent University Faculty of Medicine Ankara, Turkey, nozbek{at}ato.org.tr.

Kürsat Tokel, MD

Department of Cardiovascular Surgery, Baskent University Faculty of Medicine Ankara, Turkey

Sükrü Mercan, MD

Department of Cardiovascular Surgery, Baskent University Faculty of Medicine Ankara, Turkey

Fusun Alehan, MD

Department of Pediatrics, Baskent University Faculty of Medicine Ankara, Turkey

A 2-year-old hydrocephalic boy who had suffered multiple shunt failures was evaluated for hypercoagulability after a thrombus was removed from his right atrium. The work-up revealed that the patient had the heterozygous form of activated protein C resistance and false type 2 protein C deficiency by the clotting method. His protein C activity was normal by the chromogenic method. We suggest that patients having hydrocephalus, shunt-associated thrombus formation, or both should be evaluated for thrombophilic disorders, and protein C activity should be measured by chromogenic assay in patients with documented activated protein C resistance. (J Child Neurol 2001; 16:862-863).

Journal of Child Neurology, Vol. 16, No. 11, 862-863 (2001)
DOI: 10.1177/08830738010160111402
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