This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (33) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Yoshikawa, H. Articles by Abe, T. Search for Related Content PubMed PubMed Citation Articles by Yoshikawa, H. Articles by Abe, T. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Flu Social Bookmarking                   What's this?

Study of Influenza-Associated Encephalitis/Encephalopathy in Children During the 1997 to 2001 Influenza Seasons

Department of Pediatrics, Niigata City General Hospital, Niigata, Japan

Sawako Yamazaki, MD

Department of Pediatrics, Niigata City General Hospital, Niigata, Japan

Toru Watanabe, MD

Department of Pediatrics, Niigata City General Hospital, Niigata, Japan

Tokinari Abe, MD

Department of Pediatrics, Niigata City General Hospital, Niigata, Japan

The 1997 to 2001 influenza A epidemics in Japan were markedly neurovirulent, and many children died of influenza-associated encephalitis/encephalopathy We studied 20 patients with influenza-associated encephalitis/encephalopathy during the last four influenza seasons. No patients had been previously inoculated with influenza vaccine. Antipyretics were used in 16 patients before the onset of encephalopathy. Although all patients were treated intensively, 5 patients died and 8 had neurologic sequelae. Patients with coagulopathy, hepatic dysfunction, and computed tomographic abnormalities had a poor prognosis. The plasma concentrations of inflammatory cytokines were variable. The neuroradiologic findings could be divided into four categories. These findings indicated that the pathogenesis of the brain damage induced by influenza infection was variable. Further investigation is necessary to determine whether insufficient influenza vaccination or the use of antipyretics is one of the reasons for these epidemics of encephalopathy in Japanese children. (J Child Neurol 2001;16:885-890).

Journal of Child Neurology, Vol. 16, No. 12, 885-890 (2001)
DOI: 10.1177/088307380101601204


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. Robin, D. Ramful, F. Le Seach, M.-C. Jaffar-Bandjee, G. Rigou, and J.-L. Alessandri Neurologic Manifestations of Pediatric Chikungunya Infection J Child Neurol, September 1, 2008; 23(9): 1028 - 1035. [Abstract] [PDF]

				N. Bulakbasi, M. Kocaoglu, C. Tayfun, and T. Ucoz Transient splenial lesion of the corpus callosum in clinically mild influenza-associated encephalitis/encephalopathy. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1983 - 1986. [Abstract] [Full Text] [PDF]

				H. Tada, J. Takanashi, A. J. Barkovich, H. Oba, M. Maeda, H. Tsukahara, M. Suzuki, T. Yamamoto, T. Shimono, T. Ichiyama, et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion Neurology, November 23, 2004; 63(10): 1854 - 1858. [Abstract] [Full Text] [PDF]

				H.-S. Wang Comparison of Magnetic Resonance Imaging Abnormalities in Japanese Encephalitis and Acute Necrotizing Encephalopathy of Childhood Arch Neurol, July 1, 2004; 61(7): 1149 - 1150. [Full Text] [PDF]

				J.-i. Takanashi, A. J. Barkovich, K.-i. Yamaguchi, and Y. Kohno Influenza-Associated Encephalitis/Encephalopathy with a Reversible Lesion in the Splenium of the Corpus Callosum: A Case Report and Literature Review AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 798 - 802. [Abstract] [Full Text] [PDF]