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Journal of Child Neurology
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Tissue Inflammatory Response in Subacute Sclerosing Panencephalitis (SSPE)

Banu Anlar, MD

Department of Pediatric Neurology, Faculty of Meidcine, Hacettepe University

Figen Söylemezoglu, MD

Department of Pathology, Faculty of Medicine, Hacettepe University

Sabiha Aysun, MD

Department of Pediatric Neurology, Faculty of Meidcine, Hacettepe University

Gülsen Köse, MD

Department of Pediatric Neurology, SSK Ankara Hospital

Deniz Belen, MD

Department of Neurosurgery, SSK Ankara Hospital, Ankara, Turkey

Kalbiye Yalaz, MD

Department of Pediatric Neurology, Faculty of Meidcine, Hacettepe University

The pattern of inflammatory infiltration was studied in the frontal brain biopsies of 28 cases with subacute sclerosing panencephalitis (SSPE) by immunohistochemistry. Lymphocytic infiltration and gliosis were common pathologic findings. CD4+ T lymphocytes were often observed in perivascular areas and CD8+ lymphocytes in the parenchyma. B lymphocytes were located in large perivascular cuffs associated with longer and slower disease. Major histocompatibility complex antigens, interferon-{gamma}, and tumor necrosis factor-{alpha} (TNF-{alpha}) were expressed in endothelial and glial cells. The inflammatory lesions in subacute sclerosing panencephalitis consist of various cell subtypes and cytokines localized in particular areas of the brain tissue and show certain associations with clinical course. (J Child Neurol 2001;16:895-900).

Journal of Child Neurology, Vol. 16, No. 12, 895-900 (2001)
DOI: 10.1177/088307380101601206
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