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Pervasive Seizures Caused by Hypoxic-Ischemic Encephalopathy: Treatment With Intravenous Paraldehyde

Department of Paediatrics, Newborn Services, National Women's Hospital and The University of Auckland, New Zealand

Malcolm R. Battin, MRCP

Department of Paediatrics, Newborn Services, National Women's Hospital and The University of Auckland, New Zealand, malcolmb{at}adhb.govt.nz

Seizures are commonly associated with hypoxic-ischemic encephalopathy. Although the majority of cases are controlled with first- or second-line therapy, others develop pervasive seizures, requiring multiple anticonvulsants. To provide data on the incidence of seizures and response to anticonvulsant therapies, a cohort of 90 term infants with hypoxic-ischemic encephalopathy treated at our institution between January 1, 1995, and July 1, 1999, was reviewed. Of the 60 infants who developed seizures, 59 received phenobarbital initially; in 29 cases, the seizures resolved. The remaining 30 infants received phenytoin as a second-line anticonvulsant, and seizures stopped in 10 cases. The 20 infants with ongoing pervasive seizures were treated with intravenous paraldehyde. (J Child Neurol 2001;16:915-917).

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