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Language Dominance in Children as Determined by Magnetic Source Imaging and the Intracarotid Amobarbital Procedure: A Comparison

Department of Neurosurgery and the Vivian L. Smith Center for Neurologic Research

Panagiotis G. Simos, PhD

Department of Neurosurgery and the Vivian L. Smith Center for Neurologic Research

James W. Wheless, MD

Department of Neurology The University of Texas Health Science Center Houston, TX, Department of Pediatrics, The University of Texas Health Science Center Houston, TX

Jules E.C. Constantinou, MD

Department of Neurology The University of Texas Health Science Center Houston, TX, Department of Pediatrics, The University of Texas Health Science Center Houston, TX

James E. Baumgartner, MD

Department of Surgery The University of Texas Health Science Center; Houston, TX

Vijayalakshmi Venkataraman, MD

Department of Neurology The University of Texas Health Science Center Houston, TX

Andrew C. Papanicolaou, PhD

Department of Neurosurgery and the Vivian L. Smith Center for Neurologic Research

This study evaluated the validity of data derived from magnetic source imaging regarding hemispheric dominance for language in children and adolescents with intractable seizure disorder by comparison with results of the intracarotid amobarbital procedure. Functional imaging of the receptive language cortex using a whole-head neuromagnetometer was performed in 19 consecutive epilepsy patients, ages 8 to 18 years, who also underwent the intracarotid amobarbital procedure. During magnetic source imaging recordings, patients engaged in a continuous recognition memory task for words in visual and auditory modalities. This task has previously been shown to be valid for the purpose of lateralization and localization of language cortex in adult epilepsy patients who undergo the intracarotid amobarbital procedure and intraoperative language mapping allowing confirmation of magnetic source imaging findings. Results indicated that language laterality indices formed for the intracarotid amobarbital procedure and magnetic source imaging procedures were highly correlated (R = .87). In addition, clinical judgments regarding cerebral dominance for language made by independent raters using the two methods were in excellent agreement. We conclude that magnetic source imaging is a promising method for determination of cerebral dominance for language in children and adults. (J Child Neurol 2001;16:124-130).

Journal of Child Neurology, Vol. 16, No. 2, 124-130 (2001)
DOI: 10.1177/088307380101600211


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