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Journal of Child Neurology
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Prolonged Treatment of Refractory Status Epilepticus in a Child

Mustafa Sahin, MD, PhD

Division of Epilepsy and Clinical Neurophysiology Department of Neurology Children's Hospital Department of Neurology Harvard Medical School Boston, Massachusetts

James J. Riviello, JR, MD

Division of Epilepsy and Clinical Neurophysiology Department of Neurology Children's Hospital Department of Neurology Harvard Medical School Boston, Massachusetts

Barbiturate anesthesia, which is commonly used for refractory status epilepticus, is an effective treatment, but with many significant complications. The relationship between the duration of this extreme therapy and the ultimate outcome of refractory status epilepticus has not been well studied. We report a 7-year-old girl who presented with refractory status epilepticus secondary to presumed encephalitis with a focal lesion on cranial magnetic resonance imaging. She was treated for 70 days with high-dose antiepileptic drugs and recovered with a residual seizure disorder. This case suggests that, if the status epilepticus is due to a reversible cause such as encephalitis, neurologic recovery may occur despite this very prolonged course of extreme therapy. (J Child Neurol 2001;16:147-150).

Journal of Child Neurology, Vol. 16, No. 2, 147-150 (2001)
DOI: 10.1177/088307380101600218
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M. Sahin, C. C. Menache, G. L. Holmes, and J. J. Riviello Jr.
Prolonged treatment for acute symptomatic refractory status epilepticus: Outcome in children
Neurology, August 12, 2003; 61(3): 398 - 401.
[Abstract] [Full Text] [PDF]