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Journal of Child Neurology
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Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances in Patients With Dentatorubral-Pallidoluysian Atrophy

Yoshihiro Takeuchi, MD

Department of Pediatrics Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji

Hiroko Matsushita, MD

Department of Pediatrics Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji

Hisahiro Sakai, MD

Department of Pediatrics Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji

Hisashi Kawano, MD

Department of Pediatrics Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji

Masaharu Ochi, MD

Kyoto City Welfare Center Takeya-cho, Kamikyo-ku, Kyoto, Japan

Using a Coulochem electrode array system, we investigated the developmental changes of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy. The patterns observed in the developmental changes of tryptophan, tyrosine, homovanillic acid (HVA), 3-O-methyldopa, and 3-methoxy-4-hydroxyphenyl glycol (MHPG) in patients with dentatorubral-pallidoluysian atrophy are quite different from those in control subjects. These abnormal developmental changes in monoamine-related substances may be implicated in age-related differences in clinical symptoms of dentatorubral-pallidoluysian atrophy. (J Child Neurol 2001;16:79-82).

Journal of Child Neurology, Vol. 16, No. 2, 79-82 (2001)
DOI: 10.1177/088307380101600202
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