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Journal of Child Neurology, Vol. 16, No. 5, 380-381 (2001)
DOI: 10.1177/088307380101600515

Clonidine Treatment Increases Tics in Patients With Tourette Syndrome: Case Report

Abraham R. Kessler, PhD

Clinic for Applied Neuropsychology Rehovot, Israel

Clonidine usually serves as a tic-suppressing agent in patients with Tourette syndrome. A case study is presented in which clonidine at subclinical concentrations led to an exacerbation of the tics and caused severe systemic heat sensations. Involvement of functional abnormalities of the hypothalamus in Tourette syndrome is hypothesized. (J Child Neurol 2001;16:380-381).


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A. R. Kessler
Tourette Syndrome Associated With Body Temperature Dysregulation: Possible Involvement of an Idiopathic Hypothalamic Disorder
J Child Neurol, October 1, 2002; 17(10): 738 - 744.
[Abstract] [PDF]