This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Burd, L. Articles by Benz, B. Search for Related Content PubMed PubMed Citation Articles by Burd, L. Articles by Benz, B. Social Bookmarking                         What's this?

Long-Term Follow-up of an Epidemiologically Defined Cohort of Patients With Tourette Syndrome

Department of Neuroscience, University of North Dakata School of Medcine and Health Sciences, Grand Forks, ND, laburd{at}medicine.nodak.edu, Department of Pediatrics University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

Jacob Kerbeshian, MD

Department of Neuroscience, University of North Dakata School of Medcine and Health Sciences, Grand Forks, ND

Amy Barth, BS

Department of Pediatrics University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

Marilyn G. Klug, PhD

Department of Neuroscience, University of North Dakata School of Medcine and Health Sciences, Grand Forks, ND

Karilyn Avery, BS

Department of Pediatrics University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

Becky Benz, BS

Department of Pediatrics University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

The goal of this study was to collect prospective longitudinal information on the development of an epidemiologically defined cohort of patients with Tourette syndrome. These data may improve prognostic understanding of the condition. This information will also be important for specification of an adult phenotype for genetic marker studies. A prospective longitudinal cohort study was conducted. Fifty-four of 73 patients from our 1986 prevalence study of Tourette syndrome in North Dakota school-aged children were eligible for inclusion. The subjects were diagnosed in 1984 and 1985. We were able to interview 39 of 54 eligible patients for 507 person-years of follow-up. For the cohort, tic severity declined by 59%, global assessment of functioning improved by 50%, and the average number of comorbidities decreased by 42%. Forty-four percent of patients were essentially symptom free at follow-up. Only 22% were on medication as adults. Tourette syndrome is a developmental neuropsychiatric disorder with a long-term course that is favorable for most patients. Males demonstrated substantially more variability in improvement but overall demonstrated more improvement than females. (J Child Neurol 2001;16:431-437).

Journal of Child Neurology, Vol. 16, No. 6, 431-437 (2001)
DOI: 10.1177/088307380101600609


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L. Burd, Q. Li, J. Kerbeshian, M. G. Klug, and R. D. Freeman Tourette Syndrome and Comorbid Pervasive Developmental Disorders J Child Neurol, February 1, 2009; 24(2): 170 - 175. [Abstract] [PDF]

				B. S. Peterson, P. Thomas, M. J. Kane, L. Scahill, H. Zhang, R. Bronen, R. A. King, J. F. Leckman, and L. Staib Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome Arch Gen Psychiatry, April 1, 2003; 60(4): 415 - 424. [Abstract] [Full Text] [PDF]

				L. Burd, J. Kerbeshian, and M. G. Klug Neuropsychiatric Genetics: Misclassification in Linkage Studies of Phenotype-Genotype Research J Child Neurol, July 1, 2001; 16(7): 499 - 504. [Abstract] [PDF]