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Journal of Child Neurology
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Pseudomeningoencephalitic Presentation of Pediatric Guillain-Barré Syndrome

Deborah Young Bradshaw, MD

Department of Neurology Upstate Medical University, and State University of New York, Syracuse, NY, Children's Hospital Medical Center Boston, Harvard Medical School, Boston, MA

H. Royden Jones, MD

Lahey Clinic Medical Center Burlington, MA

Guillain-Barré syndrome is an acute, autoimmune polyradiculoneuropathy that improves with immune-modulating treatment if instituted early in the illness. Preliminary diagnosis relies on the clinician's recognition of the typical symptoms and signs as supporting evidence of the illness, such as nerve conduction studies, which may not be available emergently. We report eight children with Guillain-Barré syndrome in whom the initial presentation was atypical and suggested a primary central nervous system illness. In these patients, the predominant clinical symptoms included drowsiness, headache, irritability, and meningismus, although the classic features of Guillain-Barré syndrome (weakness, hyporeflexia) were also present. The atypical presentation caused delay in diagnosis in some cases. It is important to recognize this variant of pediatric Guillain-Barré syndrome to ensure expeditious diagnosis and treatment. (J Child Neurol 2001;16:505-508).

Journal of Child Neurology, Vol. 16, No. 7, 505-508 (2001)
DOI: 10.1177/088307380101600708
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