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Diffusion-Weighted Imaging in Moyamoya Disease

Pediatric Neurology Unit Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Masanori Takeoka, MD

Pediatric Neurology Unit Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Elizabeth C. Dooling, MD

Pediatric Neurology Unit Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Verne Caviness, MD, PhD

Pediatric Neurology Unit Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Moyamoya disease is characterized by progressive intracranial vascular stenoses of the circle of Willis, resulting in successive ischemic events. We report serial diffusion-weighted imaging studies in a case of moyamoya disease. A 4-year-old right-handed patient presented with multiple infarcts in the right and left hemispheres. Each new infarct was unambiguously recognized as bright on diffusion-weighted imaging. Previous infarcts, readily detected on other magnetic resonance imaging sequences, were not bright on diffusion-weighted imaging. The patient subsequently underwent bilateral synangiosis. In this case, the diffusion-weighted images were helpful in assessing the extent of infarcts, determining the age of the lesion, and correlation with new clinical findings. We emphasize the usefulness of diffusion-weighted imaging for following the clinical course of children with moyamoya disease, in whom new focal deficits are highly suspicious of new infarcts. (J Child Neurol 2001;16:526-530).

Journal of Child Neurology, Vol. 16, No. 7, 526-530 (2001)
DOI: 10.1177/088307380101600714


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