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Journal of Child Neurology
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Absence of Hippocampal Sclerosis in Children With Multiple Daily Seizures Since Infancy

Sanjeev V. Kothare, MD

Division of Pediatric Neurology, Department of Pediatrics University of Massachusetts Memorial Medical Center, Worcester, MA

Ana Sotrel, MD

Division of Clinical Pathology Miami Children's Hospital, FL

Michael Duchowny, MD

Department of Neurology Miami Children's Hospital, FL

Prasanna Jayakar, MD

Department of Neurology Miami Children's Hospital, FL

Paul C. Marshall

Thomas W. Smith, MD

Department of Pathology University of Massachusetts Memorial Medical Center, Worcester, MA, smitht{at}ummhc.org

We report a series of nine children with multiple daily seizures since infancy who underwent functional hemispherectomy that included en bloc resection of the hippocampus and the temporal neocortex. In all cases, the hippocampi were normal by conventional histology despite the fact that these patients had suffered from recurrent seizures over a long period of time. This observation suggests that extremely frequent seizures in childhood are not invariably associated with the development of hippocampal sclerosis. (J Child Neurol 2001;16:562-564).

Journal of Child Neurology, Vol. 16, No. 8, 562-564 (2001)
DOI: 10.1177/088307380101600804
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