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Prognostic Significance of Hyperechogenic Lesions in the Basal Ganglia and Thalamus in Neonates

Department of Internal Medicine, The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Uri Kramer, MD

Child Developmental Center and Pediatric Neurology Unit The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Zahava Stavorovsky, MD

Department of Radiology, The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Niva Shefer-Kaufmann, MD

Department of Neonatology The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Shaul Harel, MD

Child Developmental Center and Pediatric Neurology Unit The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Francis B. Mimouni, MD

Department of Neonatology The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

Shaul Dollberg, MD

Department of Neonatology The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, dolberg{at}post.tau.ac.il

Neonatal cranial ultrasonography at times reveals hyperechogenic lesions in the basal ganglia and thalamus. These lesions have been attributed to a wide variety of pathologic states, among them toxoplasmosis, rubella, cytomegalovirus, and herpes simplex (TORCH) infections, chromosomal abnormalities, and asphyxia. The clinical significance in terms of the neurodevelopmental outcome of this radiologic abnormality is unknown. We performed a developmental evaluation on 16 children aged 2 to 6 years in whom neonatal cranial ultrasonography had demonstrated hyperechogenic lesions in the basal ganglia or thalamus and had no other neurodevelopmental risk factors. There was no significant difference between the average Developmental Quotient of the target population and the normal population in regard to developmental status. We conclude that in our population, an isolated finding of hyperechogenic lesions in the basal ganglia is probably not a predictor of poor neurodevelopmental outcome. (J Child Neurol 2001;16:591-594).

Journal of Child Neurology, Vol. 16, No. 8, 591-594 (2001)
DOI: 10.1177/088307380101600810


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