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Journal of Child Neurology
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Medullomyoblastoma: Case Report

Zahid F. Cheema, MD

Department of Neurology

Thomas C. Cannon, MD, MPH

Department of Pathology

Richard Leech, MD

Department of Pathology

James Brennan, MD

Department of Neurosurgery

Adekunle Adesina, MD, PhD

Department of Pathology University of Oklahoma Oklahoma City, Oklahoma

Roger A. Brumback, MD

Department of Pathology Creighton University Medical Center Omaha, Nebraska

This 7-year-old boy presented with a 2-week history of headache, nausea, vomiting, anorexia, lethargy, and unsteadiness of gait. Brain magnetic resonance imaging (MRI) revealed a cystic mass within the vermis of the cerebellum. A suboccipital craniectomy was performed to remove a tumor that contained primitive neuroectodermal cells with florid skeletal muscle differentiation. Immunohistochemical studies and electron microscopy confirmed the presence of both a primitive neuroectodermal component and rhabdomyoblastic differentiation, consistent with the diagnosis of medullomyoblastoma. This exceedingly rare tumor of the cerebellar vermis of children is characterized by two components: primitive neuroectodermal tumor cells and skeletal muscle. Although the histogenesis remains uncertain, advances in immunohistochemistry and electron microscopy suggest the origin of this tumor from a multipotential stem cell precursor. (J Child Neurol 2001 ; 16 :598-599).

Journal of Child Neurology, Vol. 16, No. 8, 598-599 (2001)
DOI: 10.1177/088307380101600812
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