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Journal of Child Neurology
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Prenatal and Perinatal Determinants of Neonatal Seizures Occurring in the First Week of Life

Carla Arpino, MD

"E. Litta" Rehabilitation Center for Developmental Disabilities, Grottaferrata, Italy, arpinoc{at}rm.ats.it

Sergio Domizio, MD

Department of Pediatrics, University of Chieti, Chieti, Italy

Maria Patrizia Carrieri, DSc

INSERM U379, Marseilles, France

Sonia Brescianini, MSc

National Agency for Health Services, Rome, Italy

Giuseppe Sabatino, MD

Department of Pediatrics, University of Chieti, Chieti, Italy

Paolo Curatolo, MD

Pediatric Neurology Unit, "Tor Vergata" University of Rome, Rome, Italy

To evaluate prenatal and perinatal risk factors for early neonatal seizures, we conducted a case-control study including 100 newborns with neonatal seizures in the first week of life and 204 controls randomly selected from a list of healthy newborns born in the same hospital during the study period. Generalized tonic seizures were the most common seizures observed (29%), although the majority of newborns (71%) experienced more than one type of seizure. The most frequent presumed etiology of neonatal seizures was hypoxic-ischemic encephalopathy (30%). A history of epilepsy in first-degree relatives was found only for cases. Neonatal seizures were found to be associated with maternal disease in the 2 years before pregnancy, mother's weight gain > 14 kg during pregnancy, placental pathology, preeclampsia, low birthweight, low gestational age, and jaundice in the first 3 days of life. The need for cardiopulmonary resuscitation was found only for cases (37%). The causal pathways for neonatal seizures often begin before birth, and some of the factors identified may be preventable. (J Child Neurol 2001;16:651-656).

Journal of Child Neurology, Vol. 16, No. 9, 651-656 (2001)
DOI: 10.1177/088307380101600905
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