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Journal of Child Neurology
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Concentrations of Nucleotides, Nucleosides, Purine Bases, Oxypurines, Uric Acid, and Neuron-Specific Enolase in the Cerebrospinal Fluid of Children With Sepsis

Antonio Rodríguez-Núñez, MD, PhD

Department of Pediatrics Hospital Clinico Universitario de Santiago Complejo Hospitalario

Elena Cid, MD, PhD

Department of Pediatrics Hospital Clinico Universitario de Santiago Complejo Hospitalario

Javier Rodríguez-García, PhD

Department of Biochemistry School of Pharmacy

Félix Camifia, PhD

Department of Biochemistry School of Pharmacy

Santiago Rodriguez-Segade, PhD

Department of Biochemistry School of Pharmacy

Manuel Castro-Gago, MD, PhD

Department of Pediatrics Hospital Clínico Universitario de Santiago Complejo Hospitalario University of Santiago de Compostela Santiago de Compostela, Spain

To determine the effects of sepsis on cerebral energy metabolism, the cerebrospinal fluid adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, hypoxanthine, xanthine, and urate concentrations were determined by high-performance liquid chromatography and the neuron-specific enolase levels by means of an enzyme immunoassay method in 32 children with sepsis, without meningitis, aged between 2 months and 13 years, and in 160 age-matched controls. The septic group had significantly higher cerebrospinal fluid concentrations of inosine, adenosine, xanthine, and urate than controls. These results suggest that sepsis could provoke some degree of neuronal hypoxia and significant alterations of cerebral energy metabolism homeostasis. (J Child Neurol 2001;16:704-706).

Journal of Child Neurology, Vol. 16, No. 9, 704-706 (2001)
DOI: 10.1177/088307380101600918
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