Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Serdaroglu, A.
Right arrow Articles by Okuyaz, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Serdaroglu, A.
Right arrow Articles by Okuyaz, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Role of Apoptosis in Duchenne's Muscular Dystrophy

Ayse Serdaroglu, MD

Department of Pediatric Neurology Gazi University Faculty of Medicine

Kivilcim Gücüyener

Department of Pediatric Neurology Gazi University Faculty of Medicine

Sevim Erdem

Department of Neurology Hacettepe University Faculty of Medicine

Gülsen Köse

Pediatric Neurology Clinic Ankara Social Security Hospital

Ersin Tan

Department of Neurology Hacettepe University Faculty of Medicine

Çetin Okuyaz

Department of Pediatric Neurology Gazi University Faculty of Medicine Ankara, Turkey

We investigated the presence of apoptosis in muscle tissues from 24 patients (average age 5.44 ± 1.81 years) with Duchenne's muscular dystrophy by in situ tailing of nuclear fragmentation. Muscle tissue from 4 children without histologic evidence of myopathy served as normal controls. Muscle fibers positive for nuclear DNA fragmentation were determined quantitatively by counting an area of at least 400 muscle fibers. Eleven of 24 specimens showed no nuclei with DNA fragmentation. On the other hand, 0.37 ± 0.48% of fibers in patients with Duchenne's muscular dystrophy and none in controls had DNA fragmentation (P > .05). In this study, the percentage of apoptotic nuclei was higher in Duchenne's muscular dystrophy muscle than in normal controls. However, the difference did not reach a statistically significant level, and further studies with larger control groups are warranted. (J Child Neurol 2002;17:66-68).

Journal of Child Neurology, Vol. 17, No. 1, 66-68 (2002)
DOI: 10.1177/088307380201700120
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Vasc MedHome page
R. G. Mitchell, B. D. Duscha, J. L. Robbins, S. I. Redfern, J. Chung, D. R. Bensimhon, W. E. Kraus, W. R. Hiatt, J. G. Regensteiner, and B. H. Annex
Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease
Vascular Medicine, November 1, 2007; 12(4): 285 - 290.
[Abstract] [PDF]