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Journal of Child Neurology
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Lambert-Eaton Myasthenic Syndrome in Children

Chang-Yong Tsao, MD

Department of Pediatrics and Neurology, ctsao{at}chi.osu.edu

Jerry R. Mendell, MD

Department of Neurology College of Medicine and Public Health The Ohio State University

Miriam L. Friemer, MD

Department of Neurology College of Medicine and Public Health The Ohio State University

John T. Kissel, MD

Department of Neurology College of Medicine and Public Health The Ohio State University

Lambert-Eaton myasthenic syndrome is a presynaptic disorder of neuromuscular transmission. It is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction. It is most often associated with small cell carcinomas of the lung. Rare cases have been reported in children. We recently encountered two children with Lambert-Eaton myasthenic syndrome associated with antibodies to P/Q-type calcium channel but without evidence of neoplasms. Both patients showed prolonged and significant improvement following cyclosporin treatment. The diagnosis of Lambert-Eaton myasthenic syndrome should be considered in children with progressive weakness and a negative work-up for the usual causes. High-frequency repetitive nerve stimulation and P/Q-type calcium-channel antibodies may confirm the diagnosis. (J Child Neurol 2002;17:74-76).

Journal of Child Neurology, Vol. 17, No. 1, 74-76 (2002)
DOI: 10.1177/088307380201700123
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