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Interleukin-1β, Tumor Necrosis Factor-, and Nitrite Levels in Febrile Seizures

Departments of Pediatric Neurology, Akdeniz University Medical School, Antalya, Turkey, senay@ med.akdeniz.edu.tr

Ercan Mihçi, MD

Department of Pediatrics. Akdeniz University Medical School, Antalya, Turkey

Mesut Cokun, PhD

Department of Pediatric Immunology, Akdeniz University Medical School, Antalya, Turkeyc

Saadet Gümüslü, MD

Department of Biochemistry Akdeniz University Medical School, Antalya, Turkey

Tomris Özbenm, MD

Department of Biochemistry Akdeniz University Medical School, Antalya, Turkey

Olcay Yegin, MD

Department of Pediatric Immunology, Akdeniz University Medical School, Antalya, Turkeyc

Proinflammatory cytokines (such as interleukin-1β, tumor necrosis factor-) and nitric oxide are known to have both direct and indirect modulating effects on neurons and neurotoxic neurotransmitters released during excitation or inflammation. We measured interleukin-1β, tumor necrosis factor-, and nitrite levels in the peripheral blood and cerebrospinal fluid of children with febrile seizures and compared our results with those of children with febrile illnesses without seizures. Twenty-nine children with febrile seizure and 15 controls were studied. The mean concentrations of interleukin-1β and nitrite were significantly increased in the cerebrospinal fluid (P < .01) of the children with febrile seizure. There were no significant changes in serum interleukin-1β, tumor necrosis factor-, nitrite, and cerebrospinal fluid tumor necrosis factor levels. Our data support the hypothesis that increased production of interleukin-1β in the central nervous system or increased diffusion of interleukin-1β through the blood-brain barrier is involved in the pathogenesis of febrile seizures. (J Child Neurol 2002;17:749—751).

Journal of Child Neurology, Vol. 17, No. 10, 749-751 (2002)
DOI: 10.1177/08830738020170101501


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