This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (3) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Anderson, D. P. Articles by Jackson, G. Search for Related Content PubMed PubMed Citation Articles by Anderson, D. P. Articles by Jackson, G. Social Bookmarking                         What's this?

Differential Functional Magnetic Resonance Imaging Language Activation in Twins Discordant for a Left Frontal Tumor

Brain Research Institute Murdoch Children's Research Institute The University of Melbourne Brain Sciences Institute Swinburne University of Technology

A. Simon Harvey, MD, FRACP

Brain Research Institute Murdoch Children's Research Institute Department of Neurology Royal Children's Hospital, harveys{at}cryptic.rch.unimelb.edu.au, Department of Pediatrics The University of Melbourne, Department of Neurology Austin and Repatriation Medical Center

Michael M. Saling, PhD

Brain Research Institute Department of Paediatrics The University of Melbourne, Department of Neuropsychology Austin and Repatriation Medical Centre

Vicki Anderson, PhD

Brain Research Institute Murdoch Children's Research Institute Department of Psychology The University of Melbourne

Michael Kean, BAppSc

Department of Medical Imaging Royal Children's Hospital Howard Florey Institute

Rani Jacobs, BSc

Murdoch Children's Research Institute Department of Psychology The University of Melbourne

David F. Abbott, PhD

Brain Research Institute

R. Mark Wellard, PhD

Brain Research Institute Department of Paediatrics The University of Melbourne

Aina Puce, PhD

Brain Research Institute Brain Sciences Institute Swinburne University of Technology

Graeme Jackson, MD, FRACP

Brain Research Institute Department of Medicine The University of Melbourne Melbourne, Australia

Eight-year-old twins, one with a left frontal tumor and aphasic seizures, the other neurologically normal, underwent serial assessment of expressive language with functional magnetic resonance imaging and neuropsychology. The affected twin showed a significant amount of right hemisphere activation coincident with behavioral deterioration in expressive language and late growth in the tumor. This pattern of language dysfunction and the left language dominance of her co-twin suggested that the affected twin was also left dominant for language, and the significance of her right activation is discussed. We postulate that the right hemisphere activation represents a stabilizing mechanism in the context of a developmental and progressive lesion in language cortex rather than language transfer per se. (J Child Neurol 2002;17:766—769).

Journal of Child Neurology, Vol. 17, No. 10, 766-769 (2002)
DOI: 10.1177/08830738020170101801


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?