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Journal of Child Neurology
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Epilepsy, Occipital Calcifications, and Oligosymptomatic Celiac Disease in Childhood

Hugo A. Arroyo, MD

Department of Neurology, Hospital Nachional de Pediatria JP Garrahan, Buenos Aires, Argnetina, hugoarroyo{at}arnet.com.ar

Susana De Rosa, MD

Department of Gastroenterology, Hospital Nachional de Pediatria JP Garrahan, Buenos Aires, Argnetina

Victor Ruggieri, MD

Department of Neurology, Hospital Nachional de Pediatria JP Garrahan, Buenos Aires, Argnetina

María T. G. de Dávila, MD

Department of Pathology Hospital Nacional de Pediatría JP Garrahan, Buenos Aires, Argentina

Natalio Fejerman, MD

Department of Neurology, Hospital Nachional de Pediatria JP Garrahan, Buenos Aires, Argnetina

The association of epilepsy, occipital calcifications, and celiac disease has been recognized as a distinct syndrome. The objective of this study was to present the clinical, electrophysiologic, and neuroradiologic features in a series of patients with this syndrome. Thirty-two patients with the constellation of epilepsy, occipital calcifications, and celiac disease were identified in our epilepsy clinic. The mean age was 11 years and the mean length of follow-up was 7.4 years. The 1990 criteria of the European Society of Pediatric Gastroenterology and Nutrition were used to diagnose celiac disease. The Kruskal-Wallis statistics test was employed with a significance of P < .05. Thirty-one patients had partial seizures, 21 of them with symptoms related to the occipital lobe. In most patients, the epilepsy was controlled or the seizures were sporadic. Three developed severe epilepsy. Occipital calcifications were present in all cases. Computed tomography in 7 patients showed hypodense areas in the white matter around calcifications, which decreased or disappeared after a period of gluten-free diet in 3 patients. A favorable outcome of epilepsy was detected in patients with the earliest dietary therapy. This study presents the largest series of children with this syndrome outside Italy. White-matter hypodensities surrounding calcifications are rarely reported. A prompt diagnosis of celiac disease might improve the evolution of the epilepsy and may improve cognitive status. (J Child Neurol 2002;17:800—806).

Journal of Child Neurology, Vol. 17, No. 11, 800-806 (2002)
DOI: 10.1177/08830738020170110801
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