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Childhood-Onset Chronic Inflammatory Demyelinating Polyradiculoneuropathy With Cranial Nerve Involvement

Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Andrew G. Lee, MD

Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, andrew-lee{at}uiowa.edu, Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Adel K. Afifi, MD

Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, Department of Anatomy and Cell Biology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Praful Kelkar, MD

Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Randy H. Kardon, MD, PhD

Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Matthew White, MD

Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

A 17-year-old male presented with chronic diplopia and generalized motor weakness. He was previously diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy and acute disseminated encephalomyelitis in childhood. Cranial magnetic resonance imaging (MRI) revealed a rarely reported finding of thickening and enhancement of multiple cranial nerves. Nerve conduction studies and electromyography showed peripheral nerve demyelination with axonal involvement. There was improvement in the clinical examination, MRI, and electrophysiologic studies after combined corticosteroid and plasma exchange therapy. We review the clinical presentation, course, and response to therapy among children with chronic inflammatory demyelinating polyradiculoneuropathy, with specific emphasis on the frequency and pattern of cranial nerve involvement. (J Child Neurol 2002;17:819—823).

Journal of Child Neurology, Vol. 17, No. 11, 819-823 (2002)
DOI: 10.1177/08830738020170111201


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