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Journal of Child Neurology
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Supratentorial Tuber Location and Autism in Tuberous Sclerosis Complex

Nicolay Chertkoff Walz, PhD

Department of Pediatrics, Division of Psychology, Children's Hospital Medical Center, Cincinnati, Ohio, nicolay.walz{at}chmcc.org

Anna Weber Byars, PhD

Department of Pediatrics, Division of Neurology, Children's Hospital Medical Center, Cincinnati, Ohio

John C. Egelhoff, DO

Department of Radiology, Children's Hospital Medical Center, Cincinnati, Ohio

David Neal Franz, MD

Department of Pediatrics, Division of Neurology, Children's Hospital Medical Center, Cincinnati, Ohio

The high rate of autism in tuberous sclerosis complex provides an opportunity to study the pathogenesis of autism. This study investigated the relationship between a DSM-IV diagnosis of autism and tuber location in a sample of 50 individuals with tuberous sclerosis complex. Chi-square analyses revealed no differences between individuals with autism (n = 15) and those without autism (n = 35) on the occurrence of tubers in the right or left frontal, occipital, parietal, or temporal regions. There were no differences between the two groups in the occurrence of tubers in subcortical or cortical regions. In the largest sample to date, these results fail to support the hypothesis that supratentorial tuber location is a marker for autism. (J Child Neurol 2002;17:830—832).

Journal of Child Neurology, Vol. 17, No. 11, 830-832 (2002)
DOI: 10.1177/08830738020170111401
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