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Journal of Child Neurology
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Double-Blind, Placebo-Controlled Study of L-Carnosine Supplementation in Children With Autistic Spectrum Disorders

Michael G. Chez, MD

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL, mchezmd{at}interaccess.com

Cathleen P. Buchanan, PhD

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

Mary C. Aimonovitch

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

Marina Becker, RN

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

Karla Schaefer, RN

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

Carter Black, RPh

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

Jamie Komen, MA

Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL

L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with {gamma}-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. We investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Behavior, Socialization, and Communication subscales) and the Receptive One-Word Picture Vocabulary test (all P < .05). Improved trends were noted on other outcome measures. Although the mechanism of action of L-carnosine is not well understood, it may enhance neurologic function, perhaps in the enterorhinal or temporal cortex. (J Child Neurol 2002;17:833—837).

Journal of Child Neurology, Vol. 17, No. 11, 833-837 (2002)
DOI: 10.1177/08830738020170111501
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