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Journal of Child Neurology
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Migraine-Type Headaches in Children Receiving Chemotherapy and Ondansetron

Raja B. Khan, MD

Divisions of Neurology and Neuro-oncology St. Jude Children's Research Hospital Memphis, Tennessee, raja.khan{at}stjude.org

Six children developed severe daily migraine-type headaches during cancer treatment. In addition to chemotherapy drugs, all received daily doses of ondansetron, a 5-hydroxytryptamine type 3 receptor antagonist. 5-Hydroxytryptamine is considered to play a central role in migraine pathogenesis, and ondansetron may have caused headaches by producing 5-hydroxytryptamine dysfunction in the brain. All six children had either a personal or a family history of migraine, and this may be a risk factor for developing ondansetron-associated migraine-type headaches. Ondansetron-induced headaches respond to withholding the drug and to standard antimigraine medications, but further study of a larger group of patients is required to confirm this impression. (J Child Neurol 2002;17:857—858).

Journal of Child Neurology, Vol. 17, No. 11, 857-858 (2002)
DOI: 10.1177/08830738020170111706
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