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Practical Aspects of Conducting Large-Scale Functional Magnetic Resonance Imaging Studies in Children

Department of Pediatrics, Division of Neurology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, neuro{at}chmcc.org

Scott K. Holland

Department of Radiology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, Imaging Research Center, Children;s Hospital Research Foundation

Richard H. Strawsburg

Department of Pediatrics, Division of Neurology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH

Wendy Bommer

Department of Radiology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, Imaging Research Center, Children;s Hospital Research Foundation

R. Scott Dunn

Department of Radiology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, Imaging Research Center, Children;s Hospital Research Foundation

Vince J. Schmithorst

Department of Radiology, Children's Hospital Medical Center/University of Cincinnati, Cincinnati, OH, Imaging Research Center, Children;s Hospital Research Foundation

Elena Plante

Department of Speech and Hearing Sciences, University of Arizona, Arizona

The potential benefits of functional magnetic resonance imaging (MRI) for the investigation of normal development have been limited by difficulties in its use with children. We describe the practical aspects, including failure rates, involved in conducting large-scale functional MRI studies with normal children. Two hundred and nine healthy children between the ages of 5 and 18 years participated in a functional MRI study of language development. Reliable activation maps were obtained across the age range. Younger children had significantly higher failure rates than older children and adolescents. It is concluded that it is feasible to conduct large-scale functional MRI studies of children as young as 5 years old. These findings can be used by other research groups to guide study design and plans for recruitment of young subjects. (J Child Neurol 2002;17:885—889).

Journal of Child Neurology, Vol. 17, No. 12, 885-889 (2002)
DOI: 10.1177/08830738020170122201


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