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Journal of Child Neurology
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Progressive Myoclonic Epilepsies

Joan A. Conry, MD

Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, jconry{at}cnmc.org

The progressive myoclonic epilepsies are a rare but extremely debilitating group of disorders that are difficult to diagnose and even harder to treat. They represent a heterogeneous subgroup of those with secondary generalized epilepsy. Efficacy of treatment is often measured in terms of slowing a patient's inevitable decline. Reviewed here are the classification of progressive myoclonic epilepsies, features of myoclonic seizures, the five most prevalent progressive myoclonic epilepsy syndromes—Unverricht-Lundborg disease, myoclonus epilepsy with ragged red fibers (MERRF) mitochondrial disease, Lafora's disease, neuronal ceroid lipofuscinoses, and sialidoses—and current treatment options. (J Child Neurol 2002;17: S80—S84).

Journal of Child Neurology, Vol. 17, No. 1 suppl, S80-S84 (2002)
DOI: 10.1177/08830738020170011201
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