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Electroencephalographic Dipoles of Spikes With and Without Myoclonic Jerks Caused by Epilepsia Partialis Continua

Bloorview Epilepsy Research Program Department of Pediatrics The Hospital for Sick Children and the University of Toronto Yo Honda. Yosuke Hara

Hiroshi Otsubo, MD

Bloorview Epilepsy Research Program Department of Pediatrics The Hospital for Sick Children and the University of Toronto Yo Honda. Yosuke Hara

Rohit Sharma, RET

Department of Pediatrics The Hospital for Sick Children and the University of Toronto

Irene Elliott, RN, MHSc

Bloorview Epilepsy Research Program Department of Pediatrics The Hospital for Sick Children and the University of Toronto

James T. Rutka, MD, PhD

Department of Surgery The Hospital for Sick Children and the University of Toronto

Sylvester H. Chuang, MD

Department of Diagnostic Imaging The Hospital for Sick Children and the University of Toronto Toronto, Ontario, Canada

Ken-ichi Kamijo, MEng

Fundamental Research Laboratories NEC Corporation Tsukuba, Japan

Tomoharu Kiyuna, MSc

Fundamental Research Laboratories NEC Corporation Tsukuba, Japan

Toshimasa Yamazaki, PhD

Fundamental Research Laboratories NEC Corporation Tsukuba, Japan

O. Carter Snead, MD

Bloorview Epilepsy Research Program Department of Pediatrics The Hospitalfor Sick Children and the University of Toronto Toronto, Ontario, Canada

We used electroencephalographic (EEG) dipole analysis to investigate the generators of spikes with and without myoclonic jerks in a 12-year-old patient with epilepsia partialis continua secondary to left parietal cortical dysplasia. We recorded EEG and right wrist extensor electromyography (EMG) and collected 42 spikes with jerks (jerking spikes) and 42 spikes without jerks (nonjerking spikes). We applied a single moving dipole model to the individual and averaged spikes. Dipoles at the negative peak of individual jerking and nonjerking spikes were localized in the dysplastic area. At the onset of the averaged jerking spike that preceded the EMG discharges by 20 ms, the dipole was in the motor cortex, whereas for the averaged nonjerking spike, the dipole was in the sensory cortex. The dipole moment at averaged jerking spike onset was twice that of the averaged nonjerking spike. Electroencephalographic dipole analysis of averaged spikes differentiated the generator of jerking and nonjerking spikes in epilepsia partialis continua. Individual dipoles demonstrated the area of epileptogenic cortical dysplasia. (J Child Neurol 2002;17:127-131)

Journal of Child Neurology, Vol. 17, No. 2, 127-131 (2002)
DOI: 10.1177/088307380201700207


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