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Journal of Child Neurology, Vol. 17, No. 2 suppl, 2S2-2S8 (2002)
DOI: 10.1177/08830738020170020701
© 2002 SAGE Publications

Antiepileptic Drug Selection in Pediatric Epilepsy

Patricia K. Crumrine, MD

Division of Child Neurology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, 3705 Fifth Ave., Pittsburgh, PA 15213-2583, crum{at}pitt.edu.

This review article presents information concerning treatment options for various pediatric epilepsy syndromes. The decisions made in the selection of antiepileptic drugs are determined by a number of variables that include, but are exclusive of, risk of seizure recurrence, patient age, epilepsy syndrome, known drug reactions, and prognosis of the epilepsy syndrome. The review discusses issues pertinent to antiepileptic drug selection including simple pharmacokinetic principles, antiepileptic drug formulations, and information concerning clinical studies using some of the antiepileptic drugs. Information is provided concerning the issues of seizure recurrence. Suggested paradigms for antiepileptic drug selection for partial seizures are provided. A table of antiepileptic drug costs is provided for assistance in prescribing and advising families. Psychosocial issues pertinent to the treatment of children are discussed. (J Child Neurol 2002;17:2S2—2S8).


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