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Journal of Child Neurology
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*VALPROIC ACID
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Valproate-Associated Stomatitis

Melody Ryan, PharmD

Division of Pharmacy Practice and Science, College of Pharmacy Department of Neurology, College of Medicine University of Kentucky Lexington, Kentucky

Robert J. Baumann, MD

Department of Neurology and Department of Pediatrics College of Medicine University of Kentucky Lexington, Kentucky

Craig S. Miller, DMD, MS

Departments of Oral Health Practice and Microbiology and Immunology College of Dentistry and College of Medicine University of Kentucky Lexington, Kentucky

Chris Baker, RN, DMD

Department of Oral Health Science, Pediatric Dentistry Section College of Dentistry University of Kentucky Lexington, Kentucky

The purpose of this article is to report a case of severe stomatitis in a patient with pediatric epilepsy taking divalproex sodium. The case was reviewed with detailed oral examinations. This 5-year-old child developed severe stomatitis 18 months after institution of divalproex sodium. Cessation of the medication was associated with resolution of the stomatitis. A review of the pertinent literature is also provided. Stomatitis is a rare but potentially serious adverse effect of divalproex sodium administration. (J Child Neurol 2002;17: 225-227).

Journal of Child Neurology, Vol. 17, No. 3, 225-227 (2002)
DOI: 10.1177/088307380201700315
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