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Neonatal Hypocalcemic Seizures: Case Report and Literature Review

Pediatric Epilepsy The Johns Hopkins Medical Institutions Baltimore, Maryland

Mary T. Silvia, MD

Pediatrics The Johns Hopkins Medical Institutions Baltimore, Maryland

Alexander Maret, MD

Pediatric Endocrinology The Johns Hopkins Medical Institutions Baltimore, Maryland

Mauri Carakushansky, MD

Pediatric Endocrinology The Johns Hopkins Medical Institutions Baltimore, Maryland

Eileen P.G. Vining, MD

Pediatrics and Neurology The Johns Hopkins Medical Institutions Baltimore, Maryland

Seizures during the neonatal period have a broad differential diagnosis, many with a specific treatment and prognosis. In the case reported, a combination of dietary and endocrinologic abnormalities resulted in hypocalcemic seizures, which continued despite aggressive correction of serum ionized calcium levels. Serial electroencephalograms (EEG) performed during the hospitalization were markedly abnormal, and treatment with anticonvulsant drugs was considered given the persistence of seizures despite normalization of serum calcium levels. After 4 days of intravenous calcium administration, the seizure activity resolved, and the patient returned to his normal baseline level of functioning. This case highlights the clinical course of neonatal hypocalcemic seizures, EEG fmdings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness. (J Child Neurol 2002;17:236-239).

Journal of Child Neurology, Vol. 17, No. 3, 236-239 (2002)
DOI: 10.1177/088307380201700319


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