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Hydrogen Proton Magnetic Resonance Spectroscopy in Autism: Preliminary Evidence of Elevated Choline/Creatine Ratio

Departments of Neurology, Indiana University School of Medicine, Indianapolis, IN, dksokol{at}iupui.edu

David W. Dunn, MD

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN

Mary Edwards-Brown, MD

Department of Radiology, Indiana University School of Medicine, Indianapolis, IN

Judy Feinberg, PhD, OT

Department of Orthopedic Surgery Indiana University School of Medicine, Indianapolis, IN

Hydrogen proton magnetic resonance spectroscopy is only beginning to be studied in autistic individuals. We report an association between hydrogen proton magnetic resonance spectroscopy choline/creatine ratios and severity of autism as measured by the Children's Autistic Rating Scale (Pearson r = .657, P = .04) in 10 autistic children. Hydrogen proton magnetic resonance spectroscopy choline/creatine ratio measures the concentration of cytosolic choline including free choline used in the synthesis of acetylcholine. Elevation in this ratio has been interpreted as a result of membrane degradation such as caused by a tumor or, alternatively, as a result of choline synthesis associated with increased cellular proliferation. Recent neuropathologic evidence has implicated disruption of acetylcholine transmission in the brains of autistic adults. A case-controlled study of hydrogen proton magnetic resonance spectroscopy choline/creatine ratios is warranted. (J Child Neurol 2002;17:245-249).

Journal of Child Neurology, Vol. 17, No. 4, 245-249 (2002)
DOI: 10.1177/088307380201700401


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