This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sokol, D. K. Articles by Feinberg, J. Search for Related Content PubMed PubMed Citation Articles by Sokol, D. K. Articles by Feinberg, J. Social Bookmarking                   What's this?

Hydrogen Proton Magnetic Resonance Spectroscopy in Autism: Preliminary Evidence of Elevated Choline/Creatine Ratio

Departments of Neurology, Indiana University School of Medicine, Indianapolis, IN, dksokol{at}iupui.edu

David W. Dunn, MD

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN

Mary Edwards-Brown, MD

Department of Radiology, Indiana University School of Medicine, Indianapolis, IN

Judy Feinberg, PhD, OT

Department of Orthopedic Surgery Indiana University School of Medicine, Indianapolis, IN

Hydrogen proton magnetic resonance spectroscopy is only beginning to be studied in autistic individuals. We report an association between hydrogen proton magnetic resonance spectroscopy choline/creatine ratios and severity of autism as measured by the Children's Autistic Rating Scale (Pearson r = .657, P = .04) in 10 autistic children. Hydrogen proton magnetic resonance spectroscopy choline/creatine ratio measures the concentration of cytosolic choline including free choline used in the synthesis of acetylcholine. Elevation in this ratio has been interpreted as a result of membrane degradation such as caused by a tumor or, alternatively, as a result of choline synthesis associated with increased cellular proliferation. Recent neuropathologic evidence has implicated disruption of acetylcholine transmission in the brains of autistic adults. A case-controlled study of hydrogen proton magnetic resonance spectroscopy choline/creatine ratios is warranted. (J Child Neurol 2002;17:245-249).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. Gabis, Wei Huang, A. Azizian, C. DeVincent, A. Tudorica, Y. Kesner-Baruch, P. Roche, and J. Pomeroy 1H-Magnetic Resonance Spectroscopy Markers of Cognitive and Language Ability in Clinical Subtypes of Autism Spectrum Disorders J Child Neurol, July 1, 2008; 23(7): 766 - 774. [Abstract] [PDF]

				A. Safdar, N. J. Yardley, R. Snow, S. Melov, and M. A. Tarnopolsky Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation Physiol Genomics, January 17, 2008; 32(2): 219 - 228. [Abstract] [Full Text] [PDF]

				O. Oner, H. Devrimci-Ozguven, F. Oktem, B. Yagmurlu, B. Baskak, and K.M. Munir Proton MR Spectroscopy: Higher Right Anterior Cingulate N-Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1494 - 1498. [Abstract] [Full Text] [PDF]

				D. K. Sokol, Demao Chen, M. R. Farlow, D. W. Dunn, B. Maloney, J. A. Zimmer, and D. K. Lahiri High Levels of Alzheimer Beta-Amyloid Precursor Protein (APP) in Children With Severely Autistic Behavior and Aggression J Child Neurol, June 1, 2006; 21(6): 444 - 449. [Abstract] [PDF]

				M. R. Herbert Large Brains in Autism: The Challenge of Pervasive Abnormality Neuroscientist, October 1, 2005; 11(5): 417 - 440. [Abstract] [PDF]