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Journal of Child Neurology
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Myoclonic Seizures as a Main Manifestation of Epstein-Barr Virus Infection

Haim Bassan, MD

The Institute for Child Development and Pediatric Neurology Unit Tel Aviv Sourasky Medical Center

Aviva Mimouni Bloch, MD

The Institute for Child Development and Pediatric Neurology Unit Tel Aviv Sourasky Medical Center

Ronit Mesterman, MD

The Institute for Child Development and Pediatric Neurology Unit Tel Aviv Sourasky Medical Center

Ayala Assia, MD

Department of Pediatrics Dana Children's Hospital

Shaul Harel, MD

The Institute for Child Development and Pediatric Neurology Unit Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv, Israel

Aviva Fattal-Valevski, MD

The Institute for Child Development and Pediatric Neurology Unit Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv, Israel

A 15-year-old girl with clinical and serologic evidence of active Epstein-Barr virus infection presented with a new onset of myoclonic jerks, confirmed on electroencephalogram (EEG) by generalized polyspike-and-wave epileptiform activity. Family history for juvenile myoclonic epilepsy was negative, and brain magnetic resonance imaging was normal. The myoclonic jerks resolved spontaneously after 5 days, with gradual normalization of the EEG during the ensuing month and since then no resumption over the last 2 years. Previous reports have already linked Epstein-Barr virus infection to opsoclonus-myoclonus syndrome and hypsarrhythmia, but to the best of our knowledge, this is the first presentation of epileptic myoclonic jerks associated with acute Epstein-Barr virus infection. We suggest that acute myoclonic seizures with a transiently abnormal EEG and benign course can be associated with acute Epstein-Barr virus infection. (J Child Neurol 2002;17:446-447).

Journal of Child Neurology, Vol. 17, No. 6, 446-447 (2002)
DOI: 10.1177/088307380201700609
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