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Journal of Child Neurology
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Auditory Brainstem Evoked Potentials in Early-Treated Congenital Hypothyroidism

Yi-Hung Chou, MD

Division of Neonatology Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan

Pen-Jung Wang, MD, PhD

Department of Pediatrics Tzu-Chi Medical College, Hualien, Taiwan

To evaluate the effect of early treatment of congenital hypothyroidism on central nervous system development, auditory brainstem evoked potentials were determined in 32 patients with hyperthyrotropinemia diagnosed during neonatal screening. The patients included 27 with congenital hypothyroidism and 5 with transient hypothyroidism. Abnormal auditory brainstem evoked potential tracings were found in 8 patients (congenital hypothyroidism in 7 and transient hypothyroidism in 1). Four of these patients had increased peripheral conduction time (wave I prolongation), and the other 4 had increased central conduction time (wave III or V prolongation). The patients with abnormal auditory brainstem evoked potentials did not show increased initial manifestations, yet 6 of them had lower initial thyroxine levels. Specific auditory brainstem evoked potential abnormalities were found in 25% of early-treated patients with congenital hypothyroidism. The possible causal relationship between deviant auditory brainstem evoked potential patterns and later neurodevelopment demands further clarification. This study suggests the usefulness of auditory brainstem evoked potential assessment to provide information about electrophysiologic deviation of the auditory pathway in patients with early-treated congenital hypothyroidism. (J Child Neurol 2002;17:510-514).

Journal of Child Neurology, Vol. 17, No. 7, 510-514 (2002)
DOI: 10.1177/088307380201700707
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This article has been cited by other articles:


Home page
 PediatricsHome page
American Academy of Pediatrics, S. R. Rose, and the Section on Endocrinology and Committee on, American Thyroid Association, R. S. Brown, and the Public Health Committee, and Lawson Wilkins Pediatric Endocrine Society
Update of newborn screening and therapy for congenital hypothyroidism.
Pediatrics, June 1, 2006; 117(6): 2290 - 2303.
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