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Prospective Long-Term Follow-Up of Patients With Pervasive Developmental Disorders

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND, Department of Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

Jacob Kerbeshian, MD

Department of Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND

Alyssia Westerland

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND

Janelle Labine

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND

Amy Barth, BS

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND

Marilyn G. Klug, PhD

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND

Kay Wagner

Department of Pediatrics, University of North Dakota School of Meidcine and Health Sciences, Grand Forks, ND

We conducted a 12-year prospective study of children with pervasive developmental disorders from North Dakota. In a prospective longitudinal follow-up study, of 59 patients, we found 52 patients with pervasive developmental disorders (88%). Ten (17%) declined to participate. We collected data on 42 (71%) of the original cohort. Of the 42 subjects, 1 died (1.7%). The other 41 were followed up for 492 person-years. Severity scores for the Diagnostic and Statistical Manual of Mental Disorders-III-Revised (DSM-III-R) declined 20% and for DSM-IV 23%. Global Assessment of Functioning improved 19%, and the average number of comorbidities decreased 45%. Thirty-seven percent of patients improved in all four measures, whereas only 5% improved in only one measure. Pervasive developmental disorders are developmental disorders with a long-term course of limited improvement for most patients. Male subjects demonstrated substantially more variability in improvement but, overall, demonstrated more improvement than female subjects. (J Child Neurol 2002; 17:681-688).

Journal of Child Neurology, Vol. 17, No. 9, 681-688 (2002)
DOI: 10.1177/088307380201700906


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