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Journal of Child Neurology, Vol. 17, No. 9, 692-695 (2002)
DOI: 10.1177/088307380201700908
© 2002 SAGE Publications

Clinical and Macroscopic Correlates of Minicolumnar Pathology in Autism

Manuel F. Casanova, MD

Departments of Psychiatry, Neurology and Anatomy Medical College of Georgia Augusta, Georgia

Daniel P. Buxhoeveden, PhD

Department of Psychiatry Medical College of Georgia Augusta, Georgia

Caroline Brown, PhD

Department of Experimental Psychology University of Bristol Bristol, England

All subcortical arrangements are primarily nuclear in type. The cortex has been the first part of the brain to evolve a radial and laminar arrangement of cells. The resultant modular arrangement is based on the cell minicolumn: a self-contained ecosystem of connectivity linking afferent, efferent, and inerneuronal connections. Recently, the cell minicolumn has been found to be abnormal in patients with autism. This article relates different aspects of the cell minicolumn and larger-scale neuronal assemblies to potential research techniques and their application to clinical practice. (J Child Neurol 2002;17:692-695).


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