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Journal of Child Neurology
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Treatment of Subacute Sclerosing Panencephalitis With Interferon-{alpha}, Ribavirin, and Inosiplex

Tom Solomon, MRCP

Departments of Neurological Science and Medical Microbiology and Genitourinary Medicine University of Liverpool Liverpool, United Kingdom

C. Anthony Hart, FRCPath

Department of Medical Microbiology and Genitourinary Medicine University of Liverpool Liverpool, United Kingdom

Sobhan Vinjamuri, MD

Nuclear Medicine Department Royal Liverpool University Hospital Liverpool, United Kingdom

Nicholas J. Beeching, FRCP

Infectious Diseases Unit University Hospital Aintree Liverpool, United Kingdom

Conor Malucci, FRCS

Department of Neurosurgery Walton Centre for Neurology and Neurosurgery Liverpool, United Kingdom

Peter Humphrey, FRCP

Department of Neurology Walton Centre for Neurology and Neurosurgery Liverpool, United Kingdom

Subacute sclerosing panencephalitis is an almost universally fatal late complication of measles infection for which there is no established treatment. We report a patient with subacute sclerosing panencephalitis who was bed-bound and ataxic and had a left hemiparesis and frequent myoclonus. He was started on a new regimen consisting of intraventricular interferon-{alpha} (starting at 100,000 U/m2/day, building up to 1 million U/m2/day), ribavirin (60 mg/kg/day intravenously), and inosiplex (3 g/day) and improved markedly. At 10 weeks, the intraventricular reservoir was removed because of bacterial infection, and he was discharged home on oral ribavirin (1200 mg/kg/day) and inosiplex. He continued to improve as judged by neurologic examination, functional independence measurement, neuropsychometry and single photon emission computed tomography (SPECT) imaging. However, after 10 months, he deteriorated suddenly and died before further intraventricular treatment could be instituted. Further trials are needed to evaluate long-term combination therapy in subacute sclerosing panencephalitis. (J Child Neurol 2002;17:703-705).

Journal of Child Neurology, Vol. 17, No. 9, 703-705 (2002)
DOI: 10.1177/088307380201700911
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This article has been cited by other articles:


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G. G. Gascon
Randomized Treatment Study of Inosiplex Versus Combined Inosiplex and Intraventricular Interferon-{alpha} in Subacute Sclerosing Panencephalitis (SSPE): International Multicenter Study
J Child Neurol, December 1, 2003; 18(12): 819 - 827.
[Abstract] [PDF]