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Journal of Child Neurology
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Hemiconvulsion-Hemiplegia Syndrome and Elevated Interleukin-6: Case Report

Masahiko Kimura, MD

Department of Pediatrics Shimane Medical University Izumo, Japan

Masaru Tasaka, MD

Department of Pediatrics Shimane Medical University Izumo, Japan

Hitoshi Sejima, MD

Department of Pediatrics Shimane Medical University Izumo, Japan

Yuichi Takusa, MD

Department of Pediatrics Shimane Medical University Izumo, Japan

Takashi Ichiyama, MD

Department of Pediatrics School of Medicine Yamaguchi University Ube, Japan

Seiji Yamaguchi, MD

Department of Pediatrics Shimane Medical University Enya Izumo, Japan

We report a 2-year-old boy who developed hemiconvulsion-hemiplegia syndrome with left-sided hemiplegia after a seizure lasting 35 minutes. The interleukin-6 level in the cerebrospinal fluid 2 hours after seizure onset was elevated to levels seen in patients with encephalitis. At 1 year after onset of the seizure, the patient remained hemiplegic on the left side, and magnetic resonance imaging showed severe right hemispheric atrophy. Acute changes seen on imaging studies and electroencephalograms in this patient were consistent with seizure-induced brain damage. Elevation of cerebrospinal fluid interleukin-6 may be related to the severe neurologic sequelae of our patient despite the relatively short seizure duration. (J Child Neurol 2002;17:705-707).

Journal of Child Neurology, Vol. 17, No. 9, 705-707 (2002)
DOI: 10.1177/088307380201700912
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D. W. Kim, K. -K. Kim, K. Chu, C. -K. Chung, and S. K. Lee
Surgical treatment of delayed epilepsy in hemiconvulsion-hemiplegia-epilepsy syndrome
Neurology, May 27, 2008; 70(22_Part_2): 2116 - 2122.
[Abstract] [Full Text] [PDF]