This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Anlar, B. Articles by Akçören, Z. Search for Related Content PubMed PubMed Citation Articles by Anlar, B. Articles by Akçören, Z. Social Bookmarking                         What's this?

Expression of Adhesion and Extracellular Matrix Molecules in the Developing Human Brain

Department of Pediatric Neurology Hacettepe University Ankara, Turkey

Pergin Atilla, MD

Department of Histology-Embryology Hacettepe University Ankara, Turkey

A. Nur Çakar, MD

Department of Histology-Embryology Hacettepe University Ankara, Turkey

M. Faruk Kose, MD

Clinic of Obstetrics-Gynecology Social Security Hospital Ankara, Turkey

M. Sinan Beksaç

Department of Obstetrics-Gynecology Hacettepe University Ankara, Turkey

Atilla Dagdeviren, MD

Department of Histology-Embryology Hacettepe University Ankara, Turkey

Zuhal Akçören, MD

Division of Pediatric Pathology Hacettepe University Ankara, Turkey

Cell adhesion molecules and extracellular matrix molecules have important roles in cell migration and connection. Their developmental expression has not been fully described in humans. In this report, these molecules were examined by immunohistochemistry in frontal tissue samples from 14- to 28-week-old fetuses aborted for obstetric reasons (n = 20) and four fetuses with nervous system abnormalities. Neural cell adhesion molecule (NCAM), tenascin, and laminin were expressed after 17 weeks. Neural cell adhesion molecule was observed in the neuropil, whereas tenascin and laminin also had cellular and vascular expression. Thrombospondin and fibronectin, apparent after 14 weeks, showed a redistribution from periventricular to outer cortical layers after midgestation. N-cadherin and integrin were observed in mid- and late gestation. Maternal or environmental conditions seemed to influence the pattern of expression. Fetuses with nervous system abnormalities had altered expression of several molecules. The descriptive data obtained in this study might constitute a basis for further studies investigating the role of these molecules in developmental abnormalities of the brain. (J Child Neurol 2002;17:707-713).

Journal of Child Neurology, Vol. 17, No. 9, 707-713 (2002)
DOI: 10.1177/088307380201700913


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?