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Journal of Child Neurology, Vol. 17, No. 9, 713-717 (2002)
DOI: 10.1177/088307380201700914

Association Between Factor V Leiden Mutation and the Hemiconvulsion, Hemiplegia, and Epilepsy Syndrome: Report of Two Cases

Morris H. Scantlebury, MD

Department of Paediatrics Division of Neurology

Michèle David, MD

Department of Paediatrics Division of Haematology

Lionel Carmant, MD, FRCPC

Department of Paediatrics Division of Neurology Hôpital Ste-Justine Université de Montréal Montreal, Quebec

The factor V Leiden mutation is the most common hereditary cause of venous thrombosis in our population. In the pediatric population, it has been associated with cerebrovascular thrombosis, cerebral palsy, and prosencephaly in neonates. We present two children with hemiconvulsion, hemiplegia, and epilepsy syndrome in whom the cause is likely attributable to the factor V Leiden mutation. We suggest that patients presenting with hemiconvulsion, hemiplegia, and epilepsy syndrome should be routinely investigated for factor V Leiden, and, if positive, careful consideration should be given to therapeutic and prophylactic anticoagulation as this may improve long-term outcome. (J Child Neurol 2002;17:713-717).


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