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Toxic Pediatric Parkinsonism: Report of a Child With Metabolic Studies and Response to Treatment

Division of Pediatric Neurology Weill Medical College of Cornell University New York, New York

Aviva Bojko, MD

Institute of Neurology and Neurosurgery St. Barnabas Hospital West Orange, New Jersey

Linda Heier, MD

Department of Neuroradiology Weill Medical College of Cornell University New York, New York

Steven Frucht, MD

Department of Neurology Columbia University College of Physicians and Surgeons New York, New York

Toby Nygaard, MD

University of Medicine and Dentistry of New Jersey Robert Wood Johnson Campus Mercerville, New Jersey

David Edelberg, MD

Weill Medical College of Cornell University New York, New York

We successfully treated a child with parkinsonism secondary to cytosine arabinoside with levodopa/carbidopa and attempted to elucidate the pathogenesis of the disorder by sequential analysis of cerebrospinal fluid biogenic amines, sequential magnetic resonance imaging, and fluorodopa positron emission tomography, which revealed both permanent and reversible biochemical and structural alterations. The parkinsonian disorder resolved in 9 months. Metabolic changes and structural abnormalities on imaging studies were chronologically correlated with the clinical course. (J Child Neurol 2003;18:812—815).

Journal of Child Neurology, Vol. 18, No. 11, 812-815 (2003)
DOI: 10.1177/08830738030180111701


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