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Journal of Child Neurology
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Extrapontine Myelinolysis in a Pediatric Case of Diabetic Ketoacidosis and Cerebral Edema

Joshua L. Bonkowsky, MD, PhD

Department of Pediatrics and Division of Pediatric Neurology University of Utah School of Medicine Salt Lake City, Utah

Francis M. Filloux, MD

Department of Pediatrics and Division of Pediatric Neurology University of Utah School of Medicine Salt Lake City, Utah, fran.filloux{at}hsc.utah.edu

Central pontine and extrapontine myelinolysis are characterized by symmetric demyelination following rapid shifts in serum osmolality, although in extrapontine myelinolysis, demyelination is confined to the supratentorial compartment. We present a case of extrapontine myelinolysis in a 17-year-old female that occurred in the setting of diabetic ketoacidosis, cerebral edema, mannitol therapy, and meningitis. The rate of correction of this patient's glucose and electrolyte levels was within well-accepted limits. Extrapontine myelinolysis is rare in pediatric patients: there are only 12 reports of extrapontine myelinolysis in children under age 20 years and no pediatric cases of extrapontine myelinolysis or central pontine myelinolysis associated with diabetic ketoacidosis. We review the published cases of extrapontine myelinolysis and examine the underlying etiologies and electrolyte disturbances that characterize these cases. This case expands the list of conditions in which extrapontine myelinolysis occurs to include pediatric patients with complicated diabetic ketoacidosis, emphasizing the importance of sudden osmolar shifts in the genesis of this disorder. (J Child Neurol 2003; 18: 144—147).

Journal of Child Neurology, Vol. 18, No. 2, 144-147 (2003)
DOI: 10.1177/08830738030180021201
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[Abstract] [PDF]