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Journal of Child Neurology
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Unusual Side Effects of Lamotrigine Therapy

Krishna B. Das, DM, MRCPCH

Neurosciences Unit, Institute of Child Health (University College London)

Chris Harris, PhD

Department of Ophthalmology

Diane P. L. Smyth, FRCPCH

Child Development and Neurology Service, St. Mary's Hospital, London, England.

J. Helen Cross, PhD, FRCPCH

Neurosciences Unit, Institute of Child Health (University College London), hcross{at}ich.ucl.ac.uk.

An 8-year-old boy developed tremor, unsteadiness, chorea, and eye movement abnormalities on starting lamotrigine for myoclonic jerks. Investigations for a neurodegenerative disorder were negative. Symptoms and signs resolved on stopping lamotrigine. He was well and asymptomatic on follow-up after 4 years. Another 7-year-old boy who started on lamotrigine for suspected absence seizures developed abnormalities of eye movement with associated cognitive decline, which also resolved on discontinuing the medication. Eye movement abnormalities, involuntary movements, and behavioral changes appear to be unusual side effects of lamotrigine therapy. (J Child Neurol 2003;18:479—480).

Journal of Child Neurology, Vol. 18, No. 7, 479-480 (2003)
DOI: 10.1177/08830738030180070301


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This article has been cited by other articles:


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J Child Neurol, April 1, 2006; 21(4): 357 - 358.
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Home page
J Child NeurolHome page
T. A. Zesiewicz, K. L. Sullivan, and R. A. Hauser
Chorea Induced by Lamotrigine
J Child Neurol, April 1, 2006; 21(4): 357 - 357.
[PDF]


Home page
J Child NeurolHome page
J. H. Cross
Reply to Zesiewicz et al.
J Child Neurol, April 1, 2006; 21(4): 357 - 358.
[PDF]



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