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Journal of Child Neurology
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Determining the Effects of Antiepileptic Drugs on Cognitive Function in Pediatric Patients With Epilepsy

Blaise F. D. Bourgeois, MD

Department of Neurology, Harvard Medical School, and the Division of Epilepsy and Clinical Neurophysiology, Children's Hospital Boston, Boston, MA

The majority of children with epilepsy are of normal intelligence; however, a significant subset suffers from temporary or permanent cognitive impairment. Factors that affect cognitive function are myriad and include the neuropathology underlying the epilepsy, seizures, epileptiform activity, psychosocial problems, and antiepileptic drug side effects. Although cognitive impairment is often wrongly attributed to the effects of antiepileptic drugs, antiepileptic drugs do impair cognition in some children. Clinicians should be aware of the differential cognitive effects of antiepileptic drugs and should monitor cognitive function closely when adding or changing therapy. Based on published data from prospective, chronic dosing studies, phenobarbital and topiramate have the highest potential for causing cognitive dysfunction. (J Child Neurol 2004;19(Suppl 1):S15-S24).

Journal of Child Neurology, Vol. 19, No. 1 suppl, S15-S24 (2004)
DOI: 10.1177/088307380401900103
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This article has been cited by other articles:


Home page
 J Child NeurolHome page
J. M. Pellock
The Challenge of Neuropsychiatric Issues in Pediatric Epilepsy
J Child Neurol, August 1, 2004; 19(1_suppl): S1 - S5.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J. M. Pellock
Managing Behavioral and Cognitive Problems in Children With Epilepsy
J Child Neurol, August 1, 2004; 19(1_suppl): S73 - S74.
[PDF]

Home page
 J Child NeurolHome page
J. M. Pellock
The Challenge of Neuropsychiatric Issues in Pediatric Epilepsy
J Child Neurol, January 1, 2004; 19(1_suppl): S1 - S5.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J. M. Pellock
Managing Behavioral and Cognitive Problems in Children With Epilepsy
J Child Neurol, January 1, 2004; 19(1_suppl): S73 - S74.
[PDF]