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Risk Factors for Neonatal Seizures in Very Low Birthweight Infants

Population-Based Survey

Department of Neonatology, Edith Wolfson Medical Center, Holon, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, kdavid{at}post.tau.ac.il

Rina Shochat, MD

Department of Neonatology, Edith Wolfson Medical Center, Holon, Israel

Ayala Lusky, MSc

Women and Children's Health Research Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel

Brian Reichman, MBChB

Women and Children's Health Research Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

The developing brain has an increased susceptibility to seizure activity, and neonatal seizures can adversely affect neurodevelopmental outcome. This study aimed to determine the incidence of neonatal seizures in very low birthweight infants and to identify perinatal and postnatal factors associated with the occurrence of clinical seizures. A population-based cohort of 6525 very low birthweight infants born from 1995 through 1999 comprised the study group. Maternal, perinatal, or postnatal variables that showed a significant association with neonatal seizures in a univariate analysis were tested by a multiple logistic regression to assess the independent effect of each variable on the risk of seizures. The overall incidence of seizures was 5.6%. Significant independent predictors of neonatal seizures were decreasing gestational age, male gender, respiratory distress syndrome, pulmonary air leak (pneumothorax and pulmonary interstitial emphysema), intraventricular hemorrhage, periventricular leukomalacia, patent ductus arteriosus, surgical ligation of patent ductus arteriosus, necrotizing enterocolitis, and surgical treatment of necrotizing enterocolitis. Neonatal seizures appear to be associated with major morbidities and surgical interventions in very low birthweight infants. Continuous electroencephalographic monitoring could be warranted in infants following surgical treatment. (J Child Neurol 2004;19:123—128).

Journal of Child Neurology, Vol. 19, No. 2, 123-128 (2004)
DOI: 10.1177/08830738040190020701


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