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Journal of Child Neurology
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Gabapentin to Control Seizures in Children Undergoing Cancer Treatment

Raja B. Khan, MD

Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN, raja.khan{at}stjude.org.

Daniel L. Hunt, PhD

Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN

Stephen J. Thompson, MD

Department of Pediatrics, Hackensack University Medical Center, Hackensack, NJ

Hepatic clearance of chemotherapy drugs is increased by many antiepilepsy drugs. At our institution, new-onset seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer. The charts of all children given gabapentin for seizures were reviewed. At a median follow-up of 34 months, seizures were controlled in 74% of 50 children given gabapentin monotherapy as initial treatment: 91% of the leukemia group, 57% of the brain tumor group, and 75% of the other tumor group. Seizures were controlled in 49% of 59 children in whom gabapentin was added to other antiepilepsy drugs: 43% of the leukemia group, 53% of the brain tumor group, and 50% of the other tumor group. More than one seizure at presentation, focal neurologic deficits, high-dose methotrexate, brain irradiation, and T2-weighted signal abnormality around the brain tumor cavity predicted uncontrolled seizures. Only 8 children (7%) reported adverse effects, and the drug was discontinued in two. Gabapentin effectively controls seizures in children receiving chemotherapy and is well tolerated. (J Child Neurol 2004;19:97—101).

Journal of Child Neurology, Vol. 19, No. 2, 97-101 (2004)
DOI: 10.1177/08830738040190020301
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[Abstract] [Full Text]