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Journal of Child Neurology
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Ergotamine as a Possible Cause of Möbius Sequence: Additional Clinical Observation

Koenraad Smets

Neonatal Intensive Care Unit Ghent University Hospital Ghent, Belgium

Alexandra Zecic

Neonatal Intensive Care Unit Ghent University Hospital Ghent, Belgium

Jef Willems

Department of Pediatrics Ghent University Hospital Ghent, Belgium

A case of Möbius sequence after exposure to ergotamine during early development is reported. Vascular disruption is one of the theories explaining the pathogenesis of Möbius sequence. Ergotamine can cause vasospasm and a prolonged and marked increase in uterine tone. This is the second report suggesting a relation between maternal ingestion of ergotamine in early pregnancy and subsequent Möbius sequence in a child. (J Child Neurol 2004; 19:398).

Journal of Child Neurology, Vol. 19, No. 5, 398 (2004)
DOI: 10.1177/088307380401900518
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