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Journal of Child Neurology
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Spectrum of Anticonvulsant Hypersensitivity Syndrome: Controversy of Treatment

Wing-Cheong Lee, MBBS

Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong

Joy Lok-Sum Leung, MBBS

Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong

Cheuk-Wing Fung, MRCP UK

Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong

Brian Hon-Yin Chung, MBBS Hon, MRCP

Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong

Virginia Wong, MBBS, FHKAM, FRCPCH, FRCP Lond, Edinb

Department of Paediatrics and Adolescent Medicine University of Hong Kong Hong Kong

An 18-month-old girl presented with a maculopapular rash 10 days after carbamazepine treatment. Initially, she was suspected of having a viral rash owing to associated fever. She deteriorated rapidly and was suspected of having anticonvulsant hypersensitivity syndrome or Stevens-Johnson syndrome. She developed features compatible with toxic epidermal necrolysis rapidly over 24 to 36 hours. Carbamazepine was then stopped. She responded immediately to high-dose intravenous pulse methylprednisone treatment. We discuss the controversy in the management of anticonvulsant hypersensitivity syndrome, toxic epidermal necrolysis, or Stevens-Johnson syndrome with high-dose corticosteroids, intravenous immunoglobulin, and antibiotics. (J Child Neurol 2004; 19:619-623).

Journal of Child Neurology, Vol. 19, No. 8, 619-623 (2004)
DOI: 10.1177/088307380401900810
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