This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wiznitzer, M. Search for Related Content PubMed PubMed Citation Articles by Wiznitzer, M. Social Bookmarking                   What's this?

Autism and Tuberous Sclerosis

Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, Cleveland, OH, mxw12{at}cwru.edu

The co-occurrence of autism spectrum disorder and tuberous sclerosis complex has been recognized for decades. The prevalence of tuberous sclerosis complex in the autism spectrum disorder population is 1 to 4%, whereas features of autism spectrum disorder are present in 25 to 50% of individuals with tuberous sclerosis complex. The underlying reason for this association might be a nonspecific disruption of brain function owing to tuberous sclerosis complex, including tuber location, seizures and their effect on brain development, cognitive impairment, a disturbance in brain development in regions associated with autism spectrum disorder, or, less likely, a linkage between a TSC gene and an autism susceptibility gene. Awareness of the relationship between autism spectrum disorder and tuberous sclerosis complex is important during the evaluation of individuals with either disorder. Better delineation of the association and its causative factors is needed for the development of possible interventions. (J Child Neurol 2004;19:675—679).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. S. Jeste, M. Sahin, P. Bolton, G. B. Ploubidis, and A. Humphrey Characterization of Autism in Young Children With Tuberous Sclerosis Complex J Child Neurol, May 1, 2008; 23(5): 520 - 525. [Abstract] [PDF]

				C. P. Johnson, S. M. Myers, and and the Council on Children With Disabilities Identification and Evaluation of Children With Autism Spectrum Disorders Pediatrics, November 1, 2007; 120(5): 1183 - 1215. [Abstract] [Full Text] [PDF]

				A. Rzhetsky, D. Wajngurt, N. Park, and T. Zheng Probing genetic overlap among complex human phenotypes PNAS, July 10, 2007; 104(28): 11694 - 11699. [Abstract] [Full Text] [PDF]

				L. Meikle, D. M. Talos, H. Onda, K. Pollizzi, A. Rotenberg, M. Sahin, F. E. Jensen, and D. J. Kwiatkowski A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited Survival J. Neurosci., May 23, 2007; 27(21): 5546 - 5558. [Abstract] [Full Text] [PDF]

				M. F. Casanova Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy Neuroscientist, October 1, 2006; 12(5): 435 - 441. [Abstract] [PDF]

				P. Ashwood, S. Wills, and J. Van de Water The immune response in autism: a new frontier for autism research J. Leukoc. Biol., July 1, 2006; 80(1): 1 - 15. [Abstract] [Full Text] [PDF]

				V. Wong Study of the Relationship Between Tuberous Sclerosis Complex and Autistic Disorder J Child Neurol, March 1, 2006; 21(3): 199 - 204. [Abstract] [PDF]

				P. Prather and P. J. de Vries Behavioral and Cognitive Aspects of Tuberous Sclerosis Complex J Child Neurol, September 1, 2004; 19(9): 666 - 674. [Abstract] [PDF]